SAM-eis a dietary supplement to support positive mood balance, liver, and joint function.Each enteric coated tablet contains 400 mg of S-Adenosyl-methionine in the tosylate disulfate from which yields 200 mg of elemental SAM-e per tablet.Other ingredients: cellulose, mannitol, hydroxypropylmethyl-cellulose, citric acid, sodium starch glycolate, glyceryl triacetate, croscarmellose sodium, stearic acid, silica.DirectionsAs a dietary supplement, take 1 SAMe tablet twice daily between meals.Warning:Check with your doctor if you are taking MAO inhibitor drugs. Persons with Bipolar Disorder (manic depression) should not take SAM-e.